创网网站后台管理系统,品牌设计主要做什么,图片制作器app,wordpress 内链设置friendly2MR是孟德尔岁随机化研究中的一个重要补充工具#xff0c;可以批量探索因素间的因果关系#xff0c;以及快速填补缺失eaf的数据#xff0c;但是存在细微差异需要注意。
remotes::install_github(xiechengyong123/friendly2MR)
library(friendly2MR)lib… friendly2MR是孟德尔岁随机化研究中的一个重要补充工具可以批量探索因素间的因果关系以及快速填补缺失eaf的数据但是存在细微差异需要注意。
remotes::install_github(xiechengyong123/friendly2MR)
library(friendly2MR)library(friendly2MR)
#Based on TwosampleMR, to investigate the causal relationship between multiexposure and outcome
a-find_multiexposure_outcome(exposure c(ieu-b-6,ieu-b-8,ieu-b-9),outcome ieu-b-4965,write T,p1 5e-08,clump TRUE,p2 5e-08,r2 0.001,kb 10000,LD 0.8
)
#It can used to investigate the causal relationship between exposure and multioutcome: find_exposure_multioutcome
#It can also used to investigate the causal relationship between multiexposure and multioutcome:
memo-find_multiexposure_multioutcome_epigraphdb(exposure c(ukb-a-7),outcome c(ieu-a-7),pval_threshold 1e-05,write T,save_path multi.csv
)#Fill in the missing effect allele
library(TwoSampleMR)
aaa-extract_instruments(outcomesukb-b-8755,clumpTRUE, r20.001,kb10000,access_tokenNULL)
eaf-aaa$eaf.exposure
aaa$eaf.exposure-NA
abc-find_snp_add_eaf(exposureaaa)
identical(eaf,abc$eaf.exposure)
#Please pay attention to differences
cb-cbind(eaf,abc$eaf.exposure)#To find confounders
ee1-de(ieu-a-7)
confound-c(body mass index,Coronary heart disease)
expo_dat_nocon-deletion_confounding_snp(confound confound,exposure_dat aaa,query_gene NULL,query_region NULL,catalogue GWAS,pvalue 5e-08,proxies None,r2 0.8,build 37,write TRUE,save_path MR_ivs.csv
)
